Vasokonstriktion in English with contextual examples

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Edvinsson, L, Povlsen, GK, Ahnstedt, H & Waldsee, R 2014, ' CaMKII inhibition with KN93 attenuates endothelin and serotonin receptor-mediated vasoconstriction and prevents subarachnoid hemorrhage-induced deficits in sensorimotor function. Endothelin-1 (ET-1) is a 21 amino acid peptide that is produced by the vascular endothelium (click here for details). It is a very potent vasoconstrictor that binds One such vasoconstrictor was described initially by Hickey et al.1. Subsequently, in the supernatant of cultured porcine aortic endothelial cells, Yanagisawa et al2 Apr 21, 2004 Remodeling of resistance arteries is a key feature in hypertension. We studied the transition of vasoconstriction to remodeling in isolated rat Factors affecting the secretion of endothelin. ET-1 is the most potent vasoconstrictor in the ET family, exhibiting a long duration of action.

Endothelin vasoconstriction

192-194. Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift Pulmonary arterial hypertension (PAH) is a progressive and debilitating disease with limited treatment options. Although some patients do well with calcium channel blockers, most ultimately need more advanced therapy, such as prostanoids. Recently, a new class of therapeutic agents has been developed to treat these patients: the endothelin receptor antagonists (ERAs). Fingerprint Dive into the research topics of 'Endothelin induces vasoconstriction in the bone vasculature in vitro: An effect mediated by a single receptor population'. Together they form a unique fingerprint. Endothelins Medicine & Life Sciences Upregulation of endothelin ETB receptor-mediated vasoconstriction in rat coronary artery after organ culture.

Its synthesis, mainly regulated at the gene transcription level, involves processing Endothelin also could play a role in increasing blood pressure by contributing to oxidative stress. Endothelin has been shown to stimulate oxidative stress by causing up-regulation of the subunits of NAD(P)H oxidase and stimulating production of superoxide (Duerrschmidt et al., 2000). The effects of endothelin receptor blockade on the pulmonary circulation have been reported variably, possibly in relation to a more or less important associated release of endogenous nitric oxide (NO).

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We characterized the vasomotor function of TRPV1 channels in human arterioles and investigated regulation of their vasomotor function by ET-1. Summary. We investigated the effect of endothelin-1 (ET) on cytosolic free Ca 2+ concentration ( [Ca 2+] i) and intracellular Ca 2+ store in vascular smooth muscle cells (VSMCs). Using quin2 microfluorometry, effects of ET on [Ca 2+] i were investigated in rat aortic VSMCs in primary culture.

Endothelium in pharmacology: 30 years on - British

Endothelin-1 is a 21-amino-acid endothelium- derived peptide causing uniquely sustained vasoconstriction.

To examine the role of endothelin (ET) in this process, we measured plasma and urinary FT before and at intervals for two years after liver The capacity of three vasodilators that act by distinct mechanisms to reverse endothelin‐I—mediated vasoconstriction was studied in 11 healthy nonsmoking male subjects (mean age ± SEM, 26 ± 2 years Fingerprint Dive into the research topics of 'Endothelin induces vasoconstriction in the bone vasculature in vitro: An effect mediated by a single receptor population'. Together they form a unique fingerprint.
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Res. (1994);74: pp. 105-114. First, endothelin-dependent vasoconstriction is maximal at 34 μU/ml of insulin , but blocking endothelin receptors does not reveal insulin-induced dilatation at that concentration . Second, maximal NO-dependent vasodilatation occurs at a concentration of insulin of 3.4 mU/ml ( Fig. 2 ), but NOS inhibition does not reveal insulin-induced vasoconstriction at that concentration ( Fig. 3 ). Role of endothelin in intermittent hypoxia-induced hypertension.

(viktig vasodilator).
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definition av vasoconstrictive: Synonymer, antonymer och uttal

Intraportal infusion of endothelin-1 (ET-1), a potent vasoconstrictor, significantly elevates portal venous pressure. Vasoconstriction (A) and vascular smooth muscle (VSM) Ca2+responses (Band C) to 1 nM endothelin (ET)-1 in pressurized mesenteric arteries from sham and intermittently hypoxic (IH) rats. VSM Ca2+was measured with fura-2 AM. ET-1 was added to the superfusion Cardiovascular Effects of Endothelin The distribution of endothelial and smooth muscle receptors helps to explain the phenomenon that systemic administration of ET-1 causes transient vasodilation (initial endothelial ET B activation) and hypotension, followed by prolong vasoconstriction and hypertension (smooth muscle ET A and ET B activation).

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Pato- hypertension Flashcards Quizlet

The effects of porcine endothelin on the pulmonary vascular bed and systemic vascular bed were investigated in the anesth 1. The mechanism underlying the vasoconstriction induced by endothelin‐1 (ET‐1) was investigated by measuring the intracellular concentration of Ca2+ ([Ca2+]i), isometric force and phosphorylation of the myosin light chain (MLC) in endothelium‐denuded unskinned and beta‐escin‐treated skinned smooth muscle from resistance vessels of the rabbit mesentery. Recently endothelin receptor C (ETRC) was discovered, however, its functions and distribution still remain unclear. The effects mediated by ET-1 via ETRA are vasoconstriction, bronchoconstriction and secretion of … Endothelin in the pulmonary circulation with special reference to hypoxic pulmonary vasoconstriction We investigated the effect of endothelin-1 (ET) on cytosolic free Ca 2+ concentration ( [Ca 2+] i) and intracellular Ca 2+ store in vascular smooth muscle cells (VSMCs). Using quin2 microfluorometry, effects of ET on [Ca 2+] i were investigated in rat aortic VSMCs in primary culture.